ACTION AND MECHANISM

- Antithrombotic. Heparinoids such as chondroitin sulfate increase the activity of antithrombin III, resulting in an anticoagulant effect. This anticoagulant effect is not evident after topical administration, but they promote the reabsorption of local hematomas.

SENIORS

No specific problems have been described in the elderly that would require a dosage adjustment.

PATIENT ADVICE

Apply with a light massage. If you have a thrombosis, apply without massaging.
- Avoid contact with eyes and mucous membranes. Do not apply to areas of skin with wounds, irritations, or symptoms of inflammation or infection.
The duration of treatment is usually 1-2 weeks for varicose veins and less than 10 days for hematomas. If, after 5 days of varicose vein treatment, symptoms do not improve or worsen, consult your doctor and/or pharmacist.
- If you forget to apply a dose, continue with your treatment. Do not double the next dose.

CONTRAINDICATIONS

- Hypersensitivity to heparinoids or any other component of the medication.
- Active [HEMORRHAGE] or serious coagulation disorders.

EFFECTS ON DRIVING

They have not been described.

PREGNANCY

Animal safety: no teratogenic or embryotoxic effects have been observed in animals.
Safety in humans: There are no adequate and well-controlled studies in humans. Its administration is only acceptable if there are no safer therapeutic alternatives, and the benefits outweigh the potential risks.
Effects on fertility: no specific studies have been conducted on its effects on fertility.

INDICATIONS

- [VARICOSE VEINS]. Treatment of varicose vein symptoms in adults, such as heaviness or tightness in the legs.
- [HEMATOMA]. Removal of superficial hematomas caused by blows in adults and children from 1 year old.

INTERACTIONS

They have not been described.

LACTATION

It is unknown whether it is excreted in breast milk, and what the consequences might be for the infant. It is recommended to discontinue breastfeeding or avoid administering it.

CHILDREN

The safety and efficacy of this product for the treatment of varicose veins in children and adolescents under 18 years of age, and for the treatment of hematomas in children under 1 year of age, have not been evaluated, so its use is not recommended.

GUIDELINES FOR PROPER ADMINISTRATION

Apply to the skin with a light massage to promote absorption.
In the case of varicose veins associated with thrombotic processes, apply without massage.
Avoid contact with eyes and mucous membranes, as well as broken, inflamed, irritated, or infected skin. Wash your hands with water after each application.

POSOLOGY

- Adults, topical: apply a thin layer, 2-3 times a day.
- Children and adolescents under 18 years of age, topical: no dosage adjustment required.
Safety and efficacy for the treatment of varicose veins in children < 18 years and hematomas in children < 1 year have not been evaluated.
- Elderly, topical: no dosage adjustment required.
Duration of treatment: varicose vein treatment will last for 1-2 weeks, but if after 5 days of treatment there is no improvement in symptoms, or if they worsen, the patient's clinical condition should be evaluated.
The treatment for hematomas is usually less than 10 days.
Missed dose: Skip the dose and continue with your usual treatment. Do not double the next dose.

DOSAGE IN HEPATIC INSUFFICIENCY

No specific dosage recommendations have been made.

DOSAGE IN RENAL INSUFFICIENCY

No specific dosage recommendations have been made.

PRECAUTIONS

- [THROMBOEMBOLISM]. Apply the product directly, without massage.

PRECAUTIONS RELATING TO EXCIPIENTS

- Because it contains cetostearyl alcohol, it may cause local skin reactions, such as contact dermatitis.

ADVERSE REACTIONS

It is usually well tolerated and only occasionally might local adverse reactions appear in the application area.
Adverse reactions are described according to each frequency interval, being considered very common (>10%), common (1-10%), uncommon (0.1-1%), rare (0.01-0.1%), very rare (<0.01%) or of unknown frequency (cannot be estimated from the available data).
- Allergic: very rare local [HYPERSENSITIVITY REACTIONS], with [PRURITUS] or [SKIN IRRITATION], which usually disappear when treatment is discontinued.

OVERDOSE

Symptoms: there is no experience with poisonings.
Treatment: symptomatic.

COMPOSITION

Chondroitin Sulfate (Cardiovascular): 3 Milligrams - Sodium (Salt)
LANOLIN (EXCIPIENT): 75 MILLIGRAMS
METHYL PARAHYDROXYBENZOATE (E-218) (EXC): 1.6 MILLIGRAMS
PROPYL PARAHYDROXYBENZOATE (E-216) (EXC: 0.4 MILLIGRAMS
CETOSTEARYL ALCOHOL (EXCIPIENT): 31 MILLIGRAMS