Kreon 25000 capsules is indicated in the treatment of exocrine insufficiency, caused by: cystic fibrosis of the pancreas; chronic pancreatitis; pancreatectomy; total gastrectomy; partial gastric resection (Billroth I/II); neoplastic ductal obstruction (e.g., in pancreatic or common bile duct neoplasia).

Pancreatic enzyme supplementation may also be useful in the treatment of pancreatic pain or in the treatment of late allograft pancreatitis and exocrine pancreatic insufficiency in the elderly.

Composition:

• The active substance is pancreatin
• One capsule contains 300 mg (amylase 18000 U-FE, lipase 25000 U-FE, protease 1000 U-FE)
• The other ingredients are: capsule content: macrogol 4000, hypromellose phthalate, cetyl alcohol, triethyl citrate, dimethicone 1000
• Capsule: gelatin, red iron oxide (E 172), yellow iron oxide (E 172), titanium dioxide (E 171), sodium lauryl sulphate.

Method of administration:

• The dosage is adapted to individual needs and depends on the severity of the disease and the content of the food
• Unless otherwise prescribed by the doctor, in adults (including the elderly) and children: initially one or two capsules at each main meal and one capsule at each snack, then adjust the dose based on the response. Clinical experience shows that the effective dose may be between 5 and 15 capsules per day
• The capsules should be swallowed with sufficient liquid (approximately 100 ml). It is recommended to take half or one third of the total dose at the start of a meal and the remainder during the meal
• The capsules and microspheres should be swallowed whole, without chewing or swallowing
• If swallowing the capsules is difficult (e.g. in children or elderly patients), the capsules can be opened and the mini-microspheres added to a light food that does not require chewing or taken with liquid
• Any mixture of the mini-microspheres in food or liquid should be taken immediately and should not be stored
• Chewing or crushing the mini-microspheres, as well as adding the mini-microspheres to food with a pH above 5.5 destroys the protective enteric coating.

Contraindications:

Pancreatic enzymes should not be administered during the early stages of acute pancreatitis and in those patients with known hypersensitivity to pancreatin of porcine origin.

Precautions:

If you experience side effects, contact your doctor or pharmacist.

Pregnancy, breastfeeding and fertility:

• If you are pregnant or planning to become pregnant, ask your doctor or pharmacist for advice before taking any medicine
• Your doctor will decide whether you should use Kreon and at what dose. Kreon can be used during breastfeeding.

Driving and using machines:

• Kreon is unlikely to affect your ability to drive or use machines.

Presentation: 3x20 capsules